6 Best Leaky Gut Supplements Of 2022 [Science-Backed Guide]

Contents

Gut microbiomes are fickle territories and your own gut could be compromised this very moment. One of the worst digestive system problems is leaky gut syndrome, which is not a fun condition to be in.

With our Western diets and our constant use of antibiotics, it’s no wonder that a lot of us have leaky guts. Our habits and foods have destroyed our gut lining, leading to even worse internal issues that could be serious and fatal.

Thankfully, we have ways to combat leaky gut syndrome. From what to eat to how to configure your exercise, sleep, and stress management, there are plenty of treatments at your disposal.

One of the best options is a leaky gut supplement or a supplement that could improve your overall gut health.

Below, we’ll go over our hands-down favorite leaky gut supplements for effectiveness and quality, as well as get into some specific leaky gut questions.

By the end of this article, you’ll be armed with all the tools you need to heal your gut and boost your immune system, which resides in your digestive tract.

For those who want a quick overview, below is our comparison table:

 
  
 
Our ranking
What we love about it
Ratings
Top 3 Ingredients
Trusted Brand
Free Shipping
LEAKY GUT REVIVE® by Amy Myers
rogue squat rack
Our ranking : #1
What we love about it : Best Overall For Healing Leaky Gut
Ratings : Over 320 Reviews & Nearly 5 Star Rating
Top 3 Ingredients : L-Glutamine, Larch Arabinogalactan,& Marshmallow Root Powder
Trusted Brand
Free Shipping
1MD Platinum Probiotic
rogue squat rack
Our ranking : #2
What we love about it : Best Probiotic
Ratings : 1,021+ Reviews & Great Ratings
Top 3 Ingredients : Lactobacillus/Bifidobacterium probiotic strains
Trusted Brand
Free Shipping: Only on orders over $99
Just Thrive® Probiotic
rogue squat rack
Our ranking : #3
What we love about it : Research Shows Great Promise
Ratings : Over 550 Reviews & Nearly 5 Star Rating
Top 3 Ingredients : Bacillus indicus HU36, Bacillus coagulans, & Bacillus clausii
Trusted Brand
Free Shipping

Our #1 Pick for the Best Leaky Gut Supplement: LEAKY GUT REVIVE® by Amy Myers MD (Best Overall Choice)

Probiotic Brand
Features
Our rating
Leaky Gut Revive
product-image
Leaky Gut Revive
Features
  • Most well rounded supplement for healing leaky gut 
  • Proven to help with digestive health issues like constipation, bloating, gas, indigestion, and IBS
  • Highly rated – nearly perfect 5 star rating and over 315 reviews
  • Third-party tested and verified
  • Great taste – Easily dissolves in water or smoothies
  • Trusted brand name
Our Rating
Our #1 Rated
5 out of 5

Amy Myers MD Leaky Gut Revive got our #1 spot and for good reason–this stuff is amazing. 

If you are looking for a supplement to restore your gut lining and help with symptoms like constipation, bloating, gas, indigestion, and IBS, Leaky Gut Revive from Amy Myers MD, is the one to go with.

how to heal leaky gut

And with nearly a nearly perfect 5 star rating and over 313 reviews, a ton of people agree with us.

leaky gut revive reviews

Unlike other supplement options, Leaky Gut Revive is developed by a real doctor who understands how the gut works and how to repair it.

It includes a mix of ingredients that are great for our gut and have the research to back it:

  • L-glutamine: Beneficial for nourishing your gut cells (1, 2, 3)
  • Aloe extract: Restores your gut’s mucosal lining (1)
  • Licorice extract: Soothes your stomach and intestinal lining (1)
  • Larch arabinogalactan: Is a biopolymer that improves your gut’s flora and gut-mending fatty acid production
  • Slippery elm and marshmallow root: Finalize your gut repair and mucous membrane health. (1)
how leaky gut revive works

LEAKY GUT REVIVE is beneficial for those who have taken a course of antibiotics, wish to support a healthy immune system and thyroid function, or want to beat sugar cravings and maintain a healthy weight.

Dr. Amy Myera explains how Leaky Gut Revive works and the science that backs it up in this video here:

And unlike many other gut health supplements that are unpleasant to the taste, Leaky Gut Revive dissolves easily into water and smoothies, making it simple to add to your diet. I found this 2 minute video of a woman named Kat who suffered from a ton of digestive issues and experienced substantial digestive relief with Leaky Gut Revive. Her story is one many of us can relate to and shows how effective Leaky Gut Revive can be for healing a leaky gut. 

The Verdict: If you’re struggling with leaky gut issues like bloating, constipation, diarrhea, IBS, and others–this is the one you want. It’s filled with research-backed ingredients proven to cure leaky gut, is GMP 3rd party certified, and has over 353 reviews and a nearly perfect 5 star rating. I can’t recommend this one enough.

1.1 – Ingredients

  • 3000mg L-glutamine
  • 2750mg Proprietary Blend (larch arabinogalactan, marshmallow root powder, deglycyrrhizinated licorice root powder, slippery elm bark powder, aloe vera leaf powder)

1.2 – Pros

  • Includes varying ingredients for comprehensive gut health and wellness
  • Trusted brand name
  • Third-party tested and verified
  • No gluten, dairy, soy, GMOs, preservatives, dyes, or toxic ingredients

1.3 – Cons

  • More expensive than other options (but well worth the price)

Our #2 Pick for the Best Leaky Gut Supplement: 1MD Complete Probiotics Platinum (Best Probiotic For Healing Leaky Gut)

Probiotic Brand
Features
Our rating
1MD Complete Probiotics Platinum
product-image
1MD Complete Probiotics Platinum
Features
  • Contains 11 research-backed lactobacillus and bifidobacterium strains
  • Has 50 billion CFU–more than enough to heal leaky gut
  • 3rd party certified–in other words, it contains what it claims to contain
  • Has delayed-release capsule–ensures the probiotics actually make it to your gut
  • Free shipping
  • Over 1,238 reviews
Our Rating
Our #2 Rated
4.8 out of 5

At our #2 option is an amazing probiotic from 1MD called 1MD Complete Probiotics Platinum

While our #1 option focuses on effective ingredients like L-glutamine and licorice extract, 1MD is a probiotic.

And in many ways, using Amy Myers Leaky Gut protocol together with this probiotic from 1MD are very complimentary. 

The probiotics reinvigorate your gut flora, helping to improve digestion and reduce symptoms such as bloating and gas. Then, ingredients in Leaky Gut Revive help to rebuild your gut wall. 

Before I dive into 1MD as a brand, I want to take a quick dive into the research behind this one. 

1MD is made up of a lactobacillus/bifidobacterium strains, which are the most highly researched probiotic strain, and the research is overwhelming at helping leaky gut. 

Here are 3 great studies if you’re interested in diving into the research: 1, 23

1MD Detail

When choosing a probiotic, research has shown that having multiple research-backed strains for the greatest level of effectiveness–and 1MD has 11.

1MD supplement facts

It’s also important to choose a probiotic with a high amount of CFUs, short for “Colony Forming Units. This simply means how much bacteria is in each serving. 

In short, the higher CFU, the stronger its effect.

Depending on the problem you’re trying to solve, different doses are found to more beneficial. For leaky gut, studies have shown that probiotics with between 10 billion CFU to 100 billion CFU are the most effective. 

That’s a wide range–so in other words, it means the research is not so conclusive. So… that means that we don’t have to be too crazy about the CFU count and as long as you take a probiotic with a good amount of CFU, you should be good. 

1MD Platinum has 50 billion CFU–more than enough to help heal your leaky gut. 

Another thing I like about this probiotic are its 3rd party certifications. Supplements aren’t certified by a 3rd party, and studies have shown a large amount of supplements don’t contain what they say they contain–which is terrible and misleading. 

It’s why I always look for 3rd party verification–and 1MD has 2 of them–GMP and NSF.

In short, these ensure that the 1MD actually has the probiotic strains and CFU count it says it has. 

Another issue with probiotics is that they get destroyed by stomach acid before they reach the small intestine where they can help heal leaky gut issues. 1MD has a delayed-release capsule, which is a cool technology which, as you may have guessed, avoids getting dissolved by the stomach acid and stays intact before reaching the small intestine. 

Another thing I look for are reviews, and well, 1MD has a ton of them–with over 1238 reviews and a 4.9 rating, this is fantastic.

1MD Reviews

These reviews do a great job summing up the powerful effects people have received from using 1MD platinum probiotic and healing their leaky gut.

1MD Review
1MD Reviews
1MD Review

All in all, I love this probiotic from 1MD and can’t recommend it enough for helping heal issues with leaky hut. It is research-backed, 3rd party certified, and has everything you want in a probiotic. If you’re serious about healing your leaky gut, this is the one you want. 

Pros

  • Contains 11 research-backed lactobacillus and bifidobacterium strains
  • Has 50 billion CFU–more than enough to heal leaky gut
  • 3rd party certified–in other words, it contains what it claims to contain
  • Has delayed-release capsule–ensures the probiotics actually make it to your gut
  • Free shipping
  • Over 1,238 reviews 

Cons

  • N/A

Our #3 Pick for the Best Leaky Gut Supplement: Just Thrive® Probiotic (Best For Exciting New Research)

Probiotic Brand
Features
Our rating
Just Thrive Probiotic
product-image
Just Thrive Probiotic
Features
  • Proven to heal leaky gut within 30 days
  • Backed by science
  • Has 1000x better survivability rate than other probiotics
  • Highly Rated – Nearly perfect 5 star rating and over 550 reviews
  • Trusted brand name
Our Rating
Our #3 Rated
4.7 out of 5

At our #2 ranking is one of my favorite probiotic supplements from Just Thrive. And while there are a ton of probiotic supplements available, Just Thrive is a fantastic option for reasons we’ll go over below. 

just thrive probiotic

But before we do, I want to give a brief overview on why probiotics are so important for gut health. 

For starters, probiotics already exist in your body in the trillions; they are the good bacteria that resides in your gut. 

When taken as a supplement, probiotics replenish the flora in your gut, which can help restore your gut lining.

A damaged gut lining is the main component of leaky gut syndrome–you repair your digestive lining, and leaky gut syndrome goes away.

In simpler terms, by taking a great probiotic like Just Thrive that repairs your gut lining, you can prevent a lot of the issues associated with leaky gut syndrome, like:

  • Autoimmune disorders (e.g. Rheumatoid arthritis, celiac disease, and others)
  • Food allergies and sensitivities 
  • Mood imbalances, like depression and anxiety
  • Hormonal imbalances
  • Digestive issues, like bloating and diarrhea
  • Chronic disease syndrome

What I love about the Just Thrive probiotic, is that it has a 1000x better survivability rate than yogurts and other leading probiotics. 

The biggest differentiator with this probiotic is that it has a particular patented probiotic strain called Bacillus indicus HU36.

nutrition facts just thrive

This strengthens your body with powerful antioxidants that can be absorbed better through your digestive system. Plus, they’ve conducted studies that show their product heals leaky gut syndrome in participants within 30 days.

Now, the price of this supplement is a little on the high side, but what you’re paying for is quality ingredients and science-backed supplementation, which is important when choosing a probiotic. 

This video gives a good summary of how Just Thrive works to heal your leaky gut and prevent/heal the illnesses associated with it:

What’s crazy, is if you go through the reviews here, you’ll see a ton of people commenting about their chronic disease that improved, or their allergy that went away, or one even posted about how their husband’s candida was healed shortly after taking Just Thrive.

If you have challenges with candida, I highly recommend checking out our review on the best candida cleanse

improve gut health with probiotic

The Verdict: If you are having common issues associated with Leaky Gut Syndrome, I highly recommend you give this one a try. 

1.1 – Ingredients

  • 500mg Propriety Probiotic Blend (3 billion cells, including Bacillus indicus HU36, Bacillus coagulans, Bacillus clausii, and Bacillus subtilis HU58)
  • Cellulose (hypoallergenic plant fiber prebiotic)
    Hydroxypropyl methylcellulose (HPMC, a.k.a. vegetable capsule)

1.2 – Pros

  • Patented probiotic bacteria with antioxidants
  • Replenishes gut flora while feeding it with prebiotics
  • Trusted brand name
  • All-natural ingredients
  • Fast gut reparation (as quick as 30 days)

1.3 – Cons

  • More expensive (but well worth the price)
  • Studies backing up efficacy were conducted in-house

Our #4 Pick for the Best Leaky Gut Supplement: Gaia Herbs Microbiome Food (Best Prebiotic)

Probiotic Brand
Features
Our rating
Gaia Herbs Microbiome Food
product-image
Gaia Herbs Microbiome Food
Features
  • Purity-tested, vegan, dairy-free, gluten-free, soy-free
  • Trusted brand name
  • Prebiotic to help feed gut flora already in your system
  • Manufactured in the USA
  • Price-friendly
Our Rating
Our #4 Rated
4.6 out of 5

Gaia Herbs Microbiome Supplement is designed to give your microbiome everything it needs to be happy, so you know it’s chock full of ingredients designed to improve your leaky gut.

Another well-known brand backed by research and quality products, their Microbiome Food has ingredients like larch (as you saw in the previous supplement), acacia, agave, fenugreek, cinnamon, ginger, marshmallow root, and acerola, all of which aids in total gut and gut lining health.

All of these ingredients are known as prebiotics, which feeds the probiotics — gut bacteria — already living in your intestines. This plant-based prebiotic powder feeds your healthy gut flora, allowing it to combat bad bacteria and improve your immune system.

1.1 – Ingredients

  • 1343mg organic acacia gum
  • 1110mg organic acerola fruit extract
  • 848mg organic inulin (from Agave tequilana heart)
  • 505mg organic fenugreek seed
  • 1319mg Harmonizing
  • Digestive Blend (organic cinnamon bark, organic ginger root, organic marshmallow root)

1.2 – Pros

  • Purity-tested, vegan, dairy-free, gluten-free, soy-free
  • Trusted brand name
  • Prebiotic to help feed gut flora already in your system
  • Manufactured in the USA
  • Price-friendly

1.3 – Cons

  • Not the best tasting

Our #5 Pick for the Best Leaky Gut Supplement: Gaia Herbs Microbiome Cleanse

Probiotic Brand
Features
Our rating
Gaia Herbs Microbiome Cleanse
product-image
Gaia Herbs Microbiome Cleanse
Features
  • Promotes the health and function of the GI tract
  • Trusted brand-name
  • Organic ingredients
  • Manufactured in the USA
  • Price-friendly
Our Rating
Our #5 Rated
4.3 out of 5

Another great gut health supplement from Gaia Herbs, the Gaia Microbiome Cleanse deserves a spot on our list. 

Gaia Herbs put this supplement in a capsule and it includes differing ingredients from the Microbiome Food to offer other advantages to using it.

For starters, it supports your body’s natural cleansing process, which will help flush out all of the bad flora resulting in your leaky gut.

It has black walnut, Oregon grape, sweet wormwood, oregano, Andrographis, cinnamon, and peppermint.

These help reduce the heat if your digestive system is inflamed, repair the intestinal lining, and boost both your immune and digestive systems.

If you’re going with both the Microbiome Cleanse and the Microbiome Food, we suggest taking a bottle of this stuff first, followed by the Food halfway through.

So start taking the Cleanse daily, then 30 days later begin replenishing your prebiotics with the Microbiome Food. Continue to use the Microbiome Food as long as you want a healthy gut. (The Cleanse should be used for a maximum of six weeks.)

1.1 – Ingredients

  • 438mg Proprietary Extract Blend (black walnut green hulls extract, organic sweet wormwood aerial parts, organic oregano leaf, Oregon grape root, Andrographis leaf extract, organic cinnamon bark supercritical CO2 extract)
  • 37mg organic peppermint leaf essential oil
  • Vegetable glycerin
  • Sunflower lecithin
  • Water and vegan capsule (hypromellose, chlorophyll)

1.2 – Pros

  • Promotes the health and function of the GI tract
  • Trusted brand-name
  • Organic ingredients
  • Manufactured in the USA
  • Price-friendly

1.3 – Cons

  • Not to be used when pregnant or lactating
  • Contains tree nuts (black walnut), so avoid if you have nut allergies

Our #6 Pick for the Best Leaky Gut Supplement: Vital Proteins Collagen Peptides 

Probiotic Brand
Features
Our rating
Vital Proteins Collagen Peptides
product-image
Vital Proteins Collagen Peptides
Features
  • Aids the digestive system as well as other bodily functions
  • All-natural ingredients with zero artificial sweeteners
  • Trusted brand name
  • Price-friendly
Our Rating
Our #6 Rated
4 out of 5

Collagen peptides are actually terrific for revitalizing your intestinal lining.

The best collagen peptides on the market? They come from Vital Proteins, of course.

Their cost-effective collagen peptide supplement provides zero fluff, only all-natural hydrolyzed collagen from bovine hide and hyaluronic acid from sodium hyaluronate.

This acid promotes healthier skin, speeds up wound healing, lubricates bones and joints, and soothes acid reflux.

As for the peptides, they improve gut integrity, digestion, and calm the digestive tract, which is key if your gut is inflamed and leaking.

By calming down your digestive system, you allow your body to repair the lining naturally.

Packed with 18 different essential amino acids, this supplement works double-time to give your gut a healthy boost and to improve your muscle and organ functions.

So once your gut is fully repaired, the peptides can be absorbed quickly and used in other areas of the body.

1.1 – Ingredients

  • 20g hydrolyzed collagen
  • 80mg hyaluronic acid
  • 90mg vitamin C (ascorbic acid)

1.2 – Pros

  • Aids the digestive system as well as other bodily functions
  • All-natural ingredients with zero artificial sweeteners
  • Trusted brand name
  • Price-friendly

1.3 – Cons

  • Doesn’t directly repair intestinal lining; allows your body to do it naturally by calming down GI tract
 
  
 
Our ranking
What we love about it
Ratings
Top 3 Ingredients
Trusted Brand
Free Shipping
LEAKY GUT REVIVE® by Amy Myers
rogue squat rack
Our ranking : #1
What we love about it : Best Overall For Healing Leaky Gut
Ratings : Over 320 Reviews & Nearly 5 Star Rating
Top 3 Ingredients : L-Glutamine, Larch Arabinogalactan,& Marshmallow Root Powder
Trusted Brand
Free Shipping
1MD Platinum Probiotic
rogue squat rack
Our ranking : #2
What we love about it : Best Probiotic
Ratings : 1,021+ Reviews & Great Ratings
Top 3 Ingredients : Lactobacillus/Bifidobacterium probiotic strains
Trusted Brand
Free Shipping: Only on orders over $99
Just Thrive® Probiotic
rogue squat rack
Our ranking : #3
What we love about it : Research Shows Great Promise
Ratings : Over 550 Reviews & Nearly 5 Star Rating
Top 3 Ingredients : Bacillus indicus HU36, Bacillus coagulans, & Bacillus clausii
Trusted Brand
Free Shipping

What Is Leaky Gut Syndrome?

It’s a condition that affects the intestinal lining in your GI tract. When you have leaky gut syndrome, you have gaps in your intestinal wall that allows bacteria and other toxins into the bloodstream.

This can lead to a multitude of other ailments, diseases, and conditions, making it a somewhat serious problem for your health.

For some reason, many doctors and healthcare professionals don’t recognize leaky gut syndrome as a diagnosable issue, despite glaring evidence to the contrary. In any case, you might have to take your leaky gut syndrome treatment into your own hands.

What’s the Fastest Way to Heal Leaky Gut?

There are a few things you can do to help out your gut’s microbiome, including:

  • Removing toxic foods from your diet (gluten, sugar, dairy, heavily-processed, GMO crops, and alcohol)
  • Taking digestive enzymes and probiotics/prebiotics (note: some of the products listed above have digestive enzymes on top of already being a probiotic or prebiotic)
  • Reducing stress (meditation, 7-9 hours of quality sleep)
  • Eat healthy fats to feed gut lining cells
  • Add collagen to your diet (such as Vital Proteins Collagen Peptides)
  • Add cardio to your workout regimen

While these are all terrific ways to improve your overall gut health, please know that it’ll take two weeks or longer to fully repair a leaky gut.

But if you start implementing most of these habits now, you’re that much closer to a healed gut and improved digestion and immunity.

What Heals a Leaky Gut Naturally?

Probiotics add more of the healthy bacteria to the gut while crowding out the bad toxins.

They also rebuild the intestinal walls, so it’s pivotal that you start ingesting probiotics, either through a supplement or the foods you eat.

Natural probiotics come in foods like yogurt, fermented foods like kefir, kimchi, sauerkraut, and miso, sourdough bread, and some cheeses.

Other foods that aid in digestion include vegetables like eggplant, broccoli, and carrots, fruits like blueberries, grapes, and papayas, grains like oats and quinoa, and nuts and seeds.

Again, cardio, solid sleep, stress reduction, and digestive enzymes (which we get into below) are also all-natural ways to heal leaky gut syndrome quickly and effectively.

What Foods Are Good and Bad for Your Gut?

We cover most of the foods that are good for you in the previous section. Another great food group for your gut is healthy fats, which include ghee and all-natural butter.

Saturated fats are also good for your digestive system, such as coconut oil.

As for the bad foods that wreck your gut, it’s crucial to avoid specific foods that result in very unpleasant gastrointestinal issues.

These typically fall in the FODMAPs food group, which are:

  • Fermentable oligosaccharides
  • Disaccharides
  • Monosaccharides
  • Polyols

All of these are short-chain carbohydrates that resist digestion; instead, they enter your bloodstream and create gastrointestinal problems.

These foods have fructose, lactose, fructans, galactans, and polyols. In regular speak, these are apples, cherries, pears, dates, asparagus, mushrooms, onions, garlic, most beans, natural and artificial sweeteners, grains, beer, alcohol, fruit juice, and soda. (Phew!)

While this is an exhaustive list, that doesn’t mean you absolutely have to 100 percent cut all of them from your diet.

Simply limit your consumption of FODMAP foods and your symptoms should all but go away.

Pairing this limitation with a probiotic supplement and digestive enzymes and your diet should vastly improve overall digestion.

What About Digestive Enzymes?

Digestive enzymes are nutrients that are brought to the small intestine and bloodstream, where they provide the energy for organ growth and repair.

This applies to your intestinal wall, giving your cells the juice to patch up the holes of your leaky gut.

There are three main digestive enzymes:

  • Proteases: breaks down protein into peptides/amino acids
  • Lipases: breaks down fat into three fatty acids and a glycerol molecule
  • Amylases: breaks down carbohydrates into simple sugars

By using all three digestive enzymes, you can improve your digestion and eradicate your leaky gut.

Foods with digestive enzymes include pineapple, papaya, mango, bananas, honey, kefir, avocados, kimchi, sauerkraut, miso, kiwis, and ginger. Or, you can grab a digestive enzyme supplement, like:

  • Just Thrive Gluten Away (which also has probiotics and all of the benefits of their probiotic formula)
  • Amy Myers MD Complete Enzymes
  • Gaia Herbs Reflux Relief

Conclusion

Leaky gut syndrome is a difficult condition to live with, but there are plenty of treatments readily available, like our #1 option from Amy Myers–Leaky Gut Revive–to remove the pain and improve your digestive health. To learn more, check out our in-depth piece on Leaky Gut Diet Plan here.

Start by ensuring you get enough sleep, remove stress, and exercise, then move onto the supplements and diet aspect.

Over time, you can repair your intestinal lining and optimize your gut microbiome. All you have to do is treat your system with the love and respect it deserves.

Here’s to better gut health!

Still Unsure Which Option Is Best For You? Here’s The Recap, Based On Our Testing & Research

  • LEAKY GUT REVIVE® by Amy Myers MD: This is the best overall choice for healing leaky gut. It is proven to help with digestive health issues like constipation, bloating, gas, indigestion, and IBS.
  • 1MD Complete Probiotics Platinum: This is the best probiotic for healing leaky gut. It contains Lactobacillus/Bifidobacterium probiotic strains.
  • Just Thrive® Probiotic: This supplement is best for exciting new research. It contains Bacillus indicus HU36, Bacillus coagulans, and Bacillus clausii.

Daniel Maman

Daniel is a certified personal trainer (ACE), has a Bachelors of Science degree in Sports, Exercise, and Wellness, and spends his free time keeping up to date with the latest research in health and fitness. In his free time, you can find him playing basketball, doing muay thai, camping, traveling, reading, and eating tomatoes like they're apples.

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